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Steroids have been noted to exert “hazardous” effects on the structure and function of the heart muscle.
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In a 2006 essay in the FASEB Journal , the director of the Worcester Foundation for Experimental Biology said: "Another aspect of the Nobel Prizes that is a perennial topic of discussion concerns those discoveries, inventions, or advances that go unrecognized altogether. One is the birth control pill . I have just mentioned the Worcester Foundation for Biomedical Research, where pioneering work by Gregory Pincus and M. C. Chang was carried out in the 1950s that led to the first birth control pill. Pincus died in 1967—-at the tragic age of only 63, but I doubt that a Nobel Prize would have been awarded in any case. The tributaries flowing into the development of the oral contraceptive were numerous and temporally distributed across two decades, going back to the extraction of a substance from the roots of a jungle plant by Russell Marker that was readily convertible to pregnanediol and then to progesterone in two steps, the subsequent chemical synthesis of progestins by Carl Djerassi , Luis Miramontes, and George Rosenkranz , and the discovery by Gregory Pincus and . Chang at the Worcester Foundation that a compound sent to be tested by the G. D. Searle Pharmaceutical Company was, contrary to expectations, a potent anti-ovulatory progestin." [8]

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