The Oxandrolone hormone does not carry any estrogenic related side effects. It does not aromatize and cannot lead to gynecomastia or water retention due to increases in estrogen levels. It further carries no progestin related activity, which again supports no estrogenic related side effects. Due to water retention being impossible with this steroid, this will decrease the risk of high blood pressure. Excess water retention can promote high blood pressure. Some steroids that do not aromatize can lead to high blood pressure, such as Trenbolone , but Anavar is rarely associated with this trait.
However, we know very little about Omega-6 and the ‘pro-inflammatory’ eicosanoids, and more specifically when the group 2 prostaglandins are a bad inflammatory, or a good inflammatory. Obviously, we need inflammatory processes, it’s only when we enter a chronic inflammatory state, that these are potentially bad news. Then of course, we have Swiss Temple’s theory, which overcame an evil group 2 prostaglandin, with another pro-inflammatory prostaglandin (a vast oversimplification I know, but that’s the general gist). So the story is far from simple with a variety of feedforward and feedback loops within the Group 2 eicosanoids, interleukins etc then there are crossed effects from the group 1 and Group 3 eicosanoids, which are typically inhibitory to the Group 2s, and countless other interactions with other fatty acids, let alone other molecules found in each cell nucleus. So it certainly isn’t out of the realm of possibilities…..