During clinical development for the approved indications, 18560 patients were exposed to XARELTO . These included 7111 patients who received XARELTO 15 mg or 20 mg orally once daily for a mean of 19 months (5558 for 12 months and 2512 for 24 months) to reduce the risk of stroke and systemic embolism in nonvalvular atrial fibrillation (ROCKET AF); 6962 patients who received XARELTO 15 mg orally twice daily for three weeks followed by 20 mg orally once daily to treat DVT or PE (EINSTEIN DVT , EINSTEIN PE), 10 mg or 20 mg orally once daily (EINSTEIN Extension, EINSTEIN CHOICE) to reduce the risk of recurrence of DVT and/or PE; and 4487 patients who received XARELTO 10 mg orally once daily for prophylaxis of DVT following hip or knee replacement surgery (RECORD 1-3).
The dose of Nystatin for children and adults is 4-6 mL four times daily (one-half of dose in each side of mouth). The preparation should be retained in the mouth as long as possible before swallowing. Infant dose is 2 mL four times daily (in infants and young children, use dropper to place one-half of dose in each side of mouth and avoid feeding for 5 to 10 minutes). Nystatin is not absorbed by the body, so drug interactions are not expected. Tell your doctor all prescription or over-the-counter medicines and supplements you use. Nystatin should be used only when prescribed during pregnancy. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
During chelation, toxins exit the body in urine, feces and sweat, and fluids and nutrients are excreted with the toxins. Therefore, most of the side effects of oral chelation are related to the loss of fluids and nutrients. Some patients may experience fatigue due to a loss of nutrients during the process of chelation. Low blood sugar and dehydration can cause headaches. Cramping may occur and is likely caused by a loss of magnesium or dehydration due to excess sweating. Depleted zinc or vitamin B-6 levels can result in skin irritation. Convulsions or joint pain may occur if the dosage of the chelating agent is too high.