Do not stop giving your pet these drugs abruptly, as this can have life-threatening consequences. Ask your vet about weaning your dog off of them slowly. You should let your veterinarian know if your dog is on any other medications, as these can react badly with prednisone or prednisolone. A vet should be consulted for dogs that are pregnant, and puppies that are too young should not get these drugs as they can inhibit growth and cause other problems. Diabetic dogs should also not take them. Overdose can lead to itching, seizures, loss of hearing, weakness, anxiety, depression, high blood pressure, or heart problems. Follow your veterinarian’s dosage guidelines and contact your vet if you see signs of any serious symptoms.
Prednisone is used to treat the diseases or their symptoms caused by low level of corticosteroids or some other conditions of people whose level of corticosteroids is normal. These are the cases of arthritis (certain types), allergic reactions (severe cases), multiple sclerosis (when the functions of nerves are not proper), lupus (a condition when the organs are attacked by the organism) and some other conditions effecting lungs, eyes, skin, kidney’s blood, stomach, thyroid and intenstines. Cancer of some certain types are also sometimes treated with Prednisone. Prednisone refers to the corticosteroids class of medications. It replaces the coticosteroids within a human body which must be normally and naturally produced by the organism. Prednisone may come as a solution (liquid), a tablet or a concentrated solution and is taken by mouth. Your dosage and the schedule if taking the medicine will be provided by your doctor and will depend on the results of treatment. Take the cure just the way your doctor tells you, not more or lees as prescribed. The concentrated Prednisone solution is taken using the special dropper which comes in the package. The concentrated Prednisone solution may be mixed with flavored liquids (juice). Your personal doctor can change your dosage of Prednisone during the treatment to make sure that your dose is the lowest dose possible working. The dosage may also be changed if you go through a surgery, infection, illness or a serious asthma attack. Remember to tell your personal doctor if you achieve any changes in your symptoms during taking Prednisone. Don’t stop taking the medication even if you feel much better and never stop taking it without telling your doctor as it may cause extreme tiredness, weakness, changes in skin color, mouth sores, craving for salt, slowed movements, upset stomach, weight loss. Remember telling your doctor about any allergy you have to Prednisone.
I have never written a review on anything really, but I thought it was important in this case. I have been dealing with arthritis for probably 15 years. I was essentially given two choices: the first is take Allopurinol and hope it prevents me from getting sprouts. However, I would have to take a 20 mg pill every day, and this medication has upset my stomach in the past. Option two is to treat an outbreak when it occurs with the medication. I went this route, and took Colchicine, which is the medication to treat this. The problem is that it never seemed to work, and I recently had a terrible gout attack. I got Prednisone and it really worked miracles. I was probably 70% better after one full day, and now almost 100% after three days. I am more than satisfied with this medication!
The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile .    The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation , by Arthur Nobile and coworkers.  They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone . 
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I had a severe allergic reaction two weeks ago to an unknown substance, and they gave me prednisone thru IV at the ER. Then they sent me home with a 15 day taper of tablets...60mg for 5 days, 40mg for 5 days, and finally 20 mg for 5 days. They did not tell me ANYTHING about this drug, and had I known the awful way it would make me feel, I would have refused it. Throughout the time I was taking the pills, I had terrible anxiety (which, I usually have anxiety, but nothing as intense as this), crying spells, heart palpitations, trouble breathing, you name it! I spoke to my doc and some pharmacists who told me that these were all side effects of the prednisone and should subside once the drug is out of my system. Well, I took my last 20mg Friday morning (Aug 1), and have not felt much better since then. Sat and Sunday I just felt like I had the flu or something...I just wanted to sleep and I felt kind of nauseated and headachey. Luckily, though, the heart palpitations let up, so that was nice. Today, however, my anxiety is just out the roof! I don't feel tired like I did, but instead I feel almost too revved up---like my adrenal glands are overcompensating or something.
The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile .    The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation , by Arthur Nobile and coworkers.  They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone .