Intravitreal injection of steroids

Dexamethasone, a potent corticosteroid, has been shown to suppress inflammation by inhibiting oedema, fibrin deposition, capillary leakage, and phagocytic migration of the inflammatory response. Vascular Endothelial Growth Factor (VEGF) is a cytokine which is expressed at increased concentrations in the setting of macular oedema. It is a potent promoter of vascular permeability. Corticosteroids have been shown to inhibit the expression of VEGF. Additionally, corticosteroids prevent the release of prostaglandins, some of which have been identified as mediators of cystoid macular oedema.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Macugen (pegaptanib sodium injection) is a sterile, aqueous solution containing pegaptanib sodium for intravitreous injection. Macugen solution is supplied in a single-dose, pre-filled syringe.

Pegaptanib is a selective vascular endothelial growth factor (VEGF) antagonist. VEGF is a secreted protein that selectively binds and activates its receptors located primarily on the surface of vascular endothelial cells. VEGF induces angiogenesis, and increases vascular permeability and inflammation, all of which are thought to contribute to the progression of the neovascular (wet) form of age-related macular degeneration (AMD), a leading cause of blindness.

There is a potential risk of arterial thromboembolic events (ATEs) following intravitreal use of VEGF inhibitors, including EYLEA. ATEs are defined as nonfatal stroke, nonfatal myocardial infarction or vascular death (including deaths of unknown cause). The incidence of reported thromboembolic events in the wet AMD studies during the first year was % (32 out of 1824) in the combined group of patients treated with EYLEA. The incidence in the DME studies during the first year was % (19 out of 578) in the combined group of patients treated with EYLEA compared with % (8 out of 287) in the control group; from baseline to week 100, the incidence was % (37 out of 578) in the combined group of patients treated with EYLEA compared with % (12 out of 287) in the control group. There were no reported thromboembolic events in the patients treated with EYLEA in the first 6 months of the RVO studies.

Intravitreal injection of steroids

intravitreal injection of steroids

There is a potential risk of arterial thromboembolic events (ATEs) following intravitreal use of VEGF inhibitors, including EYLEA. ATEs are defined as nonfatal stroke, nonfatal myocardial infarction or vascular death (including deaths of unknown cause). The incidence of reported thromboembolic events in the wet AMD studies during the first year was % (32 out of 1824) in the combined group of patients treated with EYLEA. The incidence in the DME studies during the first year was % (19 out of 578) in the combined group of patients treated with EYLEA compared with % (8 out of 287) in the control group; from baseline to week 100, the incidence was % (37 out of 578) in the combined group of patients treated with EYLEA compared with % (12 out of 287) in the control group. There were no reported thromboembolic events in the patients treated with EYLEA in the first 6 months of the RVO studies.

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