Contoh golongan obat kortikosteroid

As compared with lidocaine, mepivacaine 5 mg kg –1 providedbetter intraoperative analgesia with no adverse effects on releaseof the tourniquet. Moreover this finding is supported by plasmaconcentrations of the drugs that were comparable 5 min afterdeflation ( () µg ml –1 for lidocaine () µg ml –1 for mepivacaine), whilst plasmaconcentrations of lidocaine decreased significantly ( ()µg ml –1 ) at 60 min as opposed to plasma concentrationsof mepivacaine that did not vary ( () µg ml –1 ).The observation of similar plasma concentrations of both anaestheticagents despite the use of almost double concentrations of mepivacainemay be explained by the vascular effects of mepivacaine (vasoconstriction)in IVRA 19 and a much more sustained release to the systemiccirculation as compared with the predominatly vasodilatory effectsof lidocaine. 20 Therefore, toxic plasma concentrations of mepivacaineare not reached rapidly as opposed to lidocaine 3 mg kg –1 when adverse events may appear within the first minute aftertourniquet release as reported by Simon and associates. 8 Onthe other hand, the relatively prolonged nature of the increasein systemic mepivacaine concentrations might produce longerterm psychometric effects. However, we did not examine thisin our study.

Contoh golongan obat kortikosteroid

contoh golongan obat kortikosteroid

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