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Milwaukee shoulder syndrome ( apatite-associated destructive arthritis ) is a rheumatological condition similar to calcium pyrophosphate dihydrate deposition disease (CPPD). It is associated with periarticular or intra-articular deposition of hydroxyapatite crystals. Crystal deposition in the joint causes the release of collagenases , serine proteases , elastases , and interleukin-1 . This precipitates acute and rapid decline in joint function and degradation of joint anatomy. Subsequently disruption of the rotator cuff ensues. [1] [2] Along with symptomatology, the disease typically presents with positive radiologic findings, often showing marked erosion of the humeral head , cartilage , capsule , and bursae . Though rare, it is most often seen in females beginning in their 50s or 60s. Diagnosis is made with arthrocentesis and Alizarin Red staining along with clinical symptoms. [3]

Ancylostoma duodenale can live only one year [ 143 , 144 ]. Female Ancylostoma duodenale produces 10,000 to 30,000 eggs per day [ 143 , 144 ]. Man is the only definite host [ 143 , 144 ]. Ancylostoma duodenale larvae can enter the human host via the oral route in addition to the skin and it can reach pulmonary circulation through the lymphatics and venules [ 143 ]. Ancylostoma duodenale larvae can developmentally get arrested in the intestine or muscle and restart development when environmental conditions become favorable [ 145 ]. Bronchitis and bronchopneumonia can occur when the larvae break through the pulmonary capillaries to enter the alveolar spaces [ 128 , 143 , 144 ]. Pulmonary larval migration can develop peripheral blood eosinophilia [ 128 , 143 , 144 ]. Hookworm larvae can release a family of protein called “ancylostoma-secreted proteins (ASP)” [ 128 , 143 , 144 ] and can secrete low-molecular weight polypeptides which inhibit clotting factor Xa and tissue factor VIIa [ 146 ]. During pulmonary larval migration, the patients may present with cough, fever, wheezing, and transient pulmonary infiltrates that are associated with blood and pulmonary eosinophilia [ 128 ]. Both albendazole (single dose of 400 mg) and mebendazole (100 mg twice daily for three days) are drugs of choice for treatment of hookworm [ 128 ]. Pyrantel pamoate (single dose of 11 mg/kg with maximum dose of 1 g, orally) is an alternative drug of choice [ 128 ]. A previous study revealed that ivermectin can effectively treat hookworm infections [ 128 ].

He is also an analyst for ESPN and ESPN2 's NFL studio programming, as well as for the networks' college football coverage. Golic joined ESPN in 1995 as a reporter/analyst for Sunday NFL Countdown . Since then he has worked as the color commentator for the Arena Football League (1996–98, 2007–present) and the NFL's Jacksonville Jaguars pre-season games (1995–98). In 1998, Golic began serving as college football analyst for ESPN and ABC , and was an original analyst for NFL 2Night (now known as NFL Live ), the five-night-per-week news and information program on ESPN2.

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