NSAIDs are not recommended during pregnancy, particularly during the third trimester . While NSAIDs as a class are not direct teratogens , they may cause premature closure of the fetal ductus arteriosus and kidney ADRs in the fetus. Additionally, they are linked with premature birth  and miscarriage .   Aspirin, however, is used together with heparin in pregnant women with antiphospholipid antibodies .  Additionally, indomethacin is used in pregnancy to treat polyhydramnios by reducing fetal urine production via inhibiting fetal kidney blood flow.
objectives: to determine the current state of renal function monitoring carried out on patients treated with nsaids. material and method: we selected patients from a primary care centre who had received nsaids for the first time. we checked if renal function was measured and/or controlled 2 months pre/6 months post-nsaid administration in order to assess if patient renal function was known at the time of prescription and afterwards. results: during the study period, there were 42 822 prescriptions made. of these, 8611 were new drug prescriptions, of which 482 (%) were nsaids in patients older than 14 years of age. a total of 450 patients (64% female) were treated with nsaids. ibuprofen (%) was the most commonly prescribed. nsaids were more frequently used in patients between 14-45 years of age. only 168 (%) patients underwent any analytical tests over the course of the study (68% female). before prescription, renal function was measured in only 14% of cases (63 patients). two patients received nsaids despite having high serum creatinine levels. during the follow-up, serum creatinine was measured in 129 patients (%). conclusions: in primary care, nsaids represent a substantial percentage of the drugs prescribed (%). ibuprofen is the most commonly prescribed. nsaids are more frequently used in women between 14-45 years. musculo-skeletal pain is the main indication for prescription. only 14% of patients receiving these drugs had previously measured levels of serum creatinine. these values are rarely taken into account when prescribing nsaids. control of renal function after nsaid prescription was unusual.