Though many people use anti-inflammatories like ibuprofen for a headache, they don't come without side effects, and some people aren't supposed to take these drugs. Ibuprofen puts people at risk of bleeds in the gastrointestinal tract and kidney damage. Using the drug in high doses also seems to raise blood pressure and increase the risk of heart attack and stroke — one reason the FDA recently warned that people should only use ibuprofen (and other "nonsteroidal anti-inflammatory drugs," NSAIDS, like naproxen) for short periods of time and in small amounts. Yet ibuprofen (as well as naproxen) has been found in a number of supplements.
Athletes, like all others, may have illnesses or conditions that require them to take particular medications. If the medication an athlete is required to take to treat an illness or condition happens to fall under the prohibited list, a therapeutic use exemption may give that athlete the authorization to take the needed medicine. Criteria for granting a therapeutic use exemption are 1.) The athlete would experience significant health problems without taking the prohibited substance or method, 2.) The therapeutic use of the substance would not produce significant enhancement of performance, and 3.) There is no reasonable therapeutic alternative to the use of the otherwise prohibited substance or method. Note hormone replacement therapy (HRT), . supplementing with prescribed testosterone in any form to raise testosterone levels due to natural decreases that occur with aging (even if to just elevate levels to within ‘normal’ ranges), is NOT considered a medicinal exception. Persons using HRT would not be eligible for WPA/NANBF/IPE competition.