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Prednisone (or prednisolone) prescribed for the rheumatoid arthritis patients produces similar effects to those produced by cortisone or hydrocortisone with respect to antirheumatic action, influences on the metabolism of nitrogen, carbohydrate, and fat, suppression of pituitary-adrenocortical function, and influences on blood cells and the basal metabolic , two important differences are note worthy:(1) prednisone is at least four or five times as potent as cortisone or hydrocortisone, both in antirheumatic effects and in most of the metabolic effects, except those relating to electrolytes; (2) prednisone has relatively less effect on the metabolism of electrolytes and hence produces less retention of sodium, chloride, and water, and less excretion of potassium, in comparison with cortisone or hydrocortisone. In the event of an excessive stress, such as a major operation, serious infection, or severe trauma, supplementary amounts of cortisone or hydrocortisone should be administered and other special precautions should be taken to avoid the consequences of pituitary-adrenocortical and hydrocortisone produce rather similar increases in blood lipids. Prednisone produces changes in circulating blood cells similar to those produced by cortisone or hydrocortisone, namely a tendency to an increase in haemoglobin and neutrophils and a decrease in lymphocytes, eosinophils, and basophils. Prednisone decreases the urinary excretion of 17-ketosteroids and increased the urinary excretion of formaldehydogenic corticosteroids. The lessened effect of prednisone on electrolytes is especially advantageous for patients who have a tendency to retain fluid or lose potassium, or for patients who require comparatively large doses of an antirheumatic steroid, as in acute rheumatic fever or a severe flare-up of systemic lupus greatest impact of all the types of steroids on osseo-integrated implants is their osteoporotic effect and the impairment of wound healing process, making the patients more vulnerable to infection.